Impact of repeated dose of stable iodine in an in utero rat model using a metabolomic approach

Impact of repeated dose of stable iodine in an in utero rat model using a metabolomic approach

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The Fukushima nuclear power plant blast resulted in the release of 131Iodine for several weeks.This unexpected issue challenged the iodin doctrine [1], in which the counter-measure is to provide a unique iodine tablet to saturate thyroid during the radioactive contamination not expected to last more than several hours.A new doctrine must be implemented to take into account Course a pied - Accessoires - Hydratation - Ceinture such case of extended exposure based on repeated iodine administration with adapted dosage.

But repeated administration of iodine can block the thyroid [2] and few scientific evidences regarding repeated iodine administration (and its potential undesirable effect) are at our disposal [3].Moreover, unborn and young children are at high risk during a nuclear incident: it is currently recognized that one of the risks of exposure to radioactive iodine is the development of thyroid cancer, especially when exposure occurred during childhood [4].Their protection is a main priority.

Our goal was to evaluate the potential undesirable effects of such repeated iodine administration in the offspring using an untargeted metabolomic approach on a BATH BOMB REVIVAL rat reproductive model.